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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mo, C. C. Cai, M. S. Li, M. L. Zhao, Z. Y. Wang, J. L. Cui, W. |
| Description | Country affiliation: China Author Affiliation: Li ML ( Department of Pathogenic Biology and Immunology, School of Basic Science, Guangzhou Medical University, Guangzhou, China.); Zhao ZY ( Department of Pathogenic Biology and Immunology, School of Basic Science, Guangzhou Medical University, Guangzhou, China.); Cui W ( Department of Pathogenic Biology and Immunology, School of Basic Science, Guangzhou Medical University, Guangzhou, China.); Mo CC ( Department of Pathogenic Biology and Immunology, School of Basic Science, Guangzhou Medical University, Guangzhou, China.); Wang JL ( Department of Pathogenic Biology and Immunology, School of Basic Science, Guangzhou Medical University, Guangzhou, China.); Cai MS ( Department of Pathogenic Biology and Immunology, School of Basic Science, Guangzhou Medical University, Guangzhou, China mingshengcai@hotmail.com.) |
| Abstract | We amplified a 816-bp sequence of the UL31 gene from the pseudorabies virus (PRV) Becker strain genome. Evidence that this was the UL31 gene was confirmed by cloning and sequencing. The PRV UL31 gene encodes a putative protein of 271-amino acid residues, which was designated the UL31 protein. Bioinformatic analysis indicated that PRV UL31 contains a conserved PHA03328 domain, closely related with the herpes virus nuclear egress lamina protein UL31 family and highly conserved among counterparts encoded by herpes UL31 genes. Nucleic acid sequence and amino acid sequence alignments demonstrated that PRV UL31 has a relatively higher homology with UL31 homologous proteins of subfamily Alphaherpesvirinae than other subfamilies. In addition, phylogenetic analysis showed that PRV UL31 has a close evolutionary relationship with members of the subfamily Alphaherpesvirinae, especially bovine herpesvirus 1 (BoHV-1), BoHV-5, equine herpesvirus 4 (EHV-4), EHV-9 and EHV-1. Antigen prediction demonstrated that several potential B-cell epitopes are located in PRV UL31. Additionally, secondary structure and three-dimension structure prediction revealed that PRV UL31 predominantly consists of -helix. Taken together, these results provide insight on the function and mechanism of UL31 during PRV infection. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-03-17 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Herpesviridae Infections Genetics Herpesvirus 1, Suid Viral Proteins Amino Acid Sequence Animals Cloning, Molecular Computational Biology Pathogenicity Nuclear Proteins Phylogeny Sequence Homology, Nucleic Acid Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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