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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sandoval-Carrillo, A. Aguilar-Duran, M. Téllez-Valencia, A. Sierra-Campos, E. Vázquez-Alaniz, F. Barraza-Salas, M. La Llave-León, O. Salas-Pacheco, J. M. Castellanos-Juárez, F. X. |
| Spatial Coverage | Mexico |
| Description | Author Affiliation: Sandoval-Carrillo A ( Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México.); Aguilar-Duran M ( Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México.); Vázquez-Alaniz F ( Hospital General de Durango, Secretaría de Salud, Durango, México.); Castellanos-Juárez FX ( Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México.); Barraza-Salas M ( Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México.); Sierra-Campos E ( Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Durango, México.); Téllez-Valencia A ( Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Durango, México.); La Llave-León O ( Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México.); Salas-Pacheco JM ( Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México jsalas_pacheco@hotmail.com.) |
| Abstract | Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutathione S-transferases (GST) M1 and T1 genes and the risk of preeclampsia. This case-control study involved 112 preeclamptic and 233 normoevolutive pregnant women. The null polymorphisms were genotyped by multiplex polymerase chain reaction (PCR). Our results showed an increased risk of preeclampsia in patients with the GSTT1 null genotype [odds ratio (OR) = 2.21; 95% confidence interval (CI) = 1.14-4.27; P = 0.018]. Our data further showed that a combination of deletion genotypes of the GSTM1 and GSTT1 genes conferred an even higher risk of preeclampsia (OR = 4.56, 95%CI = 1.59-13.09; P = 0.005). Our results provide the first evidence suggesting that a GSTT1 null polymorphism might be associated with preeclampsia in the Mexican mestizo population, and that this risk increases with the combination of both GSTT1 and GSTM1 null polymorphisms. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-01-17 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Genetic Predisposition To Disease Glutathione Transferase Genetics Polymorphism, Genetic Pre-eclampsia Epidemiology Adolescent Alleles Case-control Studies Gene Frequency Genotype Mexico Odds Ratio Pregnancy Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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