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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, L. Wu, J. B. Wei, L. X. Wang, W. M. Shu, G. Y. Zhang, X. H. Liang, S. F. |
| Description | Country affiliation: China Author Affiliation: Wei LX ( Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China lixinwei66@126.com.); Chen L ( Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.); Wang WM ( Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.); Zhang XH ( Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.); Wu JB ( Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.); Liang SF ( Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.); Shu GY ( Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.) |
| Abstract | To investigate the effect of the HMG-CoA reductase inhibitor lovastatin on the expression of the receptor for hepatic low-density lipoprotein (LDL) in a rat model with kidney disease, and to identify the mechanisms in statin treatment of nephrotic syndrome with hyperlipidemia, a rat model with nephrotic syndrome was established. Thirty male Sprague-Dawley rats were treated with lovastatin for 2 weeks using gavage. The expression of protein and mRNA of the LDL receptor in the rat liver was detected with Western blot and RT-PCR, respectively, and blood-biochemical indices were also recorded for each group. Compared with the untreated control group, lovastatin treatment significantly decreased the levels of serum total cholesterol, LDL cholesterol, triglycerides, and urinary protein. In addition, lovastatin treatment significantly increased the levels of serum albumin and hepatic LDL receptor proteins, but had no effect on the expression of hepatic LDL receptor mRNA. Treatment with lovastatin markedly increased the expression of the hepatic LDL receptor in rats with nephrotic syndrome, which was accompanied by significantly improved hyperlipidemia. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-19 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Anticholesteremic Agents Administration & Dosage Hyperlipidemias Drug Therapy Lovastatin Nephrotic Syndrome Receptors, Ldl Genetics Metabolism Animals Therapeutic Use Cholesterol, Ldl Blood Disease Models, Animal Complications Liver Drug Effects Pathology Rats, Sprague-dawley Triglycerides Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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