NDLI: Numeric and volumetric changes in Leydig cells during aging of rats

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Neves, Bruno Vinicius Duarte Lorenzini, Fernando Veronez, Djanira Miranda, Eduardo Pereira de Neves, Gabriela Duarte Fraga, Rogério de
Abstract	Abstract Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number. Methods: Seventy-two Wistar rats were divided into six subgroups of 12 rats, which underwent right orchiectomy at 3, 6, 9, 12, 18, and 24 months of age. The weight and volume of the resected testicles were assessed. A stereological study of Leydig cells was conducted, which included measurements of cell number and nuclear, cytoplasmic, and total cell volumes. Results: The weight and volume of the resected testicles showed reductions with age. Only the subgroup composed of 24-month old rats showed a decrease in the nuclear volume of Leydig cells. Significant reductions in the cytoplasmic volume and total volume of Leydig cells were observed in 18- and 24-month old rats. The number of Leydig cells did not vary significantly with age. Conclusions: Aging in rats resulted in reduction of the nuclear, cytoplasmic, and total cell volumes of Leydig cells. There was no change in the total number of these cells during aging.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502017001000807&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000807&lng=en&nrm=iso
Starting Page	807
Ending Page	815
Page Count	9
File Format	PDF
ISSN	01028650
DOI	10.1590/s0102-865020170100000002
Journal	Acta Cirurgica Brasileira
Issue Number	10
Volume Number	32
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2017-10-01
Access Restriction	Open
Subject Keyword	Aging Leydig Cells Testis Hypogonadism Testosterone Rats
Content Type	Text
Resource Type	Article
Subject	Surgery

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Endosialin defines human stem Leydig cells with regenerative potential

Aging and declining testosterone: past, present, and hopes for the future.

Effects of aging and macrophages on mice stem Leydig cell proliferation and differentiation in vitro

Editorial: Aging and male hypogonadism

Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

In Vitro Differentiation of Leydig Cells From hiPSCs: A First Step Towards a Cellular Therapy for Hypogonadism?

Hypogonadism and Cryptorchidism

Development of a cryopreservation protocol for Leydig cells

Chronic stress induces ageing-associated degeneration in rat Leydig cells.

Numeric and volumetric changes in Leydig cells during aging of rats

Similar Documents

Endosialin defines human stem Leydig cells with regenerative potential

Aging and declining testosterone: past, present, and hopes for the future.

Effects of aging and macrophages on mice stem Leydig cell proliferation and differentiation in vitro

Editorial: Aging and male hypogonadism

Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

In Vitro Differentiation of Leydig Cells From hiPSCs: A First Step Towards a Cellular Therapy for Hypogonadism?

Hypogonadism and Cryptorchidism

Development of a cryopreservation protocol for Leydig cells

Chronic stress induces ageing-associated degeneration in rat Leydig cells.

Numeric and volumetric changes in Leydig cells during aging of rats