NDLI: Obesity and abdominal wound healing in rats

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Biondo-Simões, Maria de Lourdes Pessole Zammar, Guilherme Roberto Fernandes, Rodrigo dos Santos Biondo-Simões, Rachel Mello, Flavia Stica Ritzdorf de Noronha, Lucia de
Abstract	INTRODUCTION: Treatment for obesity essentially has to do with weight loss, which can be achieved through surgical procedures. Despite the considerable rise in the number of such procedures, the relationship between obesity and the healing process has not been totally clarified. PURPOSE: To investigate abdominal wound healing in obese Wistar rats on the seventh and fourteenth days following a laparotomy. METHODS: Thirty-six Wistar rats were randomly distributed into two groups, the control and experiment group. The control group were fed on either a standard diet for the species and the experiment group were put on a high calorie diet. After 116 days, all the animals were submitted to a laparotomy followed by laparorrhaphy. After euthanasia on the seventh or fourteenth day, fragments of the abdominal wound containing the scar were submitted to histopathological and tensiometric analysis. RESULTS: The average weight of the animals from the experiment group was higher than that of the control group (p<0.001). The difference in the resistance of the cutaneous scars was not significant. The aponeurotic scars were more resistant in the control group after seven days (p=0.011) and fourteen days (p=0.040). There was no difference in terms of intensity of the inflammatory reaction and the collagen density was similar in both groups. CONCLUSION: In rats, obesity lowered the resistance of the aponeurotic scars but not the skin scars. It did not interfere with the delayed inflammatory response and the collagen density.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502010000100018&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000100018&lng=en&nrm=iso
Starting Page	86
Ending Page	92
Page Count	7
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502010000100018
Journal	Acta Cirurgica Brasileira
Issue Number	1
Volume Number	25
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2010-02-01
Publisher Institution	PUCPR Scientific Methodology PUCPR Student, Scientific Initiation Program PUCPR Scientific Initiation Program PUCPR Division of Pathology
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Wound Healing Obesity Collagen Rats Cicatrização de Feridas Obesidade Colágeno Ratos
Alternative Title	Obesidade e cicatrização da parede abdominal em ratos
Content Type	Text
Resource Type	Article
Subject	Surgery

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