NDLI: Terazosin and propranolol as blockers to the deleterious effect of nicotine in a random skin flap, in the rat

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Fonseca, Andre V. Ferreira, Lydia Masako Gomes, Heitor C. Percário, Sandro
Abstract	PURPOSE: To evaluate the effect of Terazosin and Propranolol on the prevention of necrosis induced by nicotine, in a random skin flap. METHODS: This study utilized 32 adult male Wistar-EPM rats divided, at random, into four groups of eight animals each. All the 32 animals received nicotine (2 mg/kg/day) subcutaneously, for one week before and one week after flap elevation. CG (Control) group received distilled water (0.2 ml/day) by gavage and saline (0.5 ml) intraperitoneally, for seven days in the postoperative period. TG (Terazosin) group received terazosin hydrochloride (3 mg/day) by gavage and saline, intraperitoneally, for seven days in the postoperative period. PG (Propranolol) group received propranolol (1.5 mg/day) intraperitoneally and distilled water, by gavage, following the stablished pattern. TPG (Terazosin + Propranolol) group received both drugs. On the seventh postoperative day, the distal necrotic area of the flaps was determined via the paper template method. Blood and skin samples were collected in order to allow determination of Malondialdehyde (MDA) levels RESULTS: The control group had a mean value of 39.5 % of necrosis; the Terazosin group 25.1 %; the Propranolol group 34.5 % and the Terazosin + Propranolol group 26.2 % of necrosis. MDA levels in the serum and in the skin samples behave similarly, with an exception regarding Propranolol group in this case. CONCLUSION: Terazosin is effective in the prevention of necrosis in this animal model and Propranolol is not effective in this case.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502004000300004&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502004000300004&lng=en&nrm=iso
Starting Page	186
Ending Page	195
Page Count	10
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502004000300004
Journal	Acta Cirurgica Brasileira
Issue Number	3
Volume Number	19
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2004-06-01
Publisher Institution	Universidade Federal de São Paulo Escola Paulista de Medicina Universidade Federal de São Paulo Escola Paulista de Medicina Plastic Surgery Division Universidade Federal de São Paulo Escola Paulista de Medicina Vascular Surgery Division
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Surgical flaps Nicotine Lipid peroxidation Terazosin Propranolol Rats Retalhos cirúrgicos Nicotina Peroxidação lipídica Terazosina Ratos
Alternative Title	Terazosina e propanolol como bloqueadores do efeito deletério da nicotina em um retalho cutâneo randômico, no rato
Content Type	Text
Resource Type	Article
Subject	Surgery

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