NDLI: C-reactive protein and vasospasm after aneurysmal subarachnoid hemorrhage1

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Romero, Flávio Ramalho Cataneo, Daniele Cristina Cataneo, Antonio José Maria
Abstract	PURPOSE: To evaluate the relationship between C reactive protein levels and clinical and radiological parameters with delayed ischemic neurological deficits and outcome after aneurysmal subarachnoid hemorrhage.METHODS: One hundred adult patients with aneurismal SAH were prospectively evaluated. Besides the baseline characteristics, daily C-reactive protein levels were prospectively measured until day 10 after subarachnoid hemorrhage. The primary end point was outcome assessed by Glasgow Outcome Scale, the secondary was the occurrence of delayed ischemic neurological deficits (DINDs).RESULTS:A progressive increase in the CRP levels from the admission to 3rd postictal day was observed, followed by a slow decrease until the 9th day. Hemodynamic changes in TCD were associated with higher serum CRP levels. Patients with lower GCS scores presented with increased CRP levels. Patients with higher Hunt and Hess grades on admission developed significantly higher CRP serum levels. Patients with higher admission Fisher grades showed increased levels of CRP. A statistically significant inverse correlation was established in our series between CRP serum levels and GOS on discharge and CRP levels.CONCLUSIONS:Higher C-reactive protein serum levels are associated with worse clinical outcome and the occurrence of delayed ischemic neurological deficits. Because C-reactive protein levels were significantly elevated in the early phase, they might be a useful parameter to monitor.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502014000500340&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500340&lng=en&nrm=iso
Starting Page	340
Ending Page	345
Page Count	6
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502014000500009
Journal	Acta Cirurgica Brasileira
Issue Number	5
Volume Number	29
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2014-05-01
Access Restriction	Open
Subject Keyword	C-Reactive Protein Vasospasm, Intracranial Subarachnoid Hemorrhage
Content Type	Text
Resource Type	Article
Subject	Surgery

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C-reactive protein and vasospasm after aneurysmal subarachnoid hemorrhage.

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