NDLI: The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Oliveira, Teresinha Regina Ribeiro de Oliveira, Geraldo Ferreira de Simões, Ricardo Santos Tikazawa, Eduardo Hiroshi Monteiro, Hugo Pequeno Fagundes, Djalma José Taha, Murched Omar
Abstract	Abstract Purpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N=6): (CG): no clamping of the superior mesenteric artery (90 min.); (IR-SS): saline + ischemia (30 min.) + reperfusion (60 min.); (IR-PTX): PTX + ischemia (30min.) + reperfusion (60 min.); (IPC-IR-SS): 5 min. of ischemia + 5 minutes of reperfusion (IPC) + saline + ischemia (30 min.) + reperfusion (60 min.); (IPC-IR-PTX ): 5 min. of ischemia + 5 min. of reperfusion (IPC) + PTX + 30 min. of I + 60 minutes of R. Results: The IR-PTX, IPC-IR-SS and IPC-IR-PTX groups had significantly lower scores of mucosa damage than the IR-SS group. IR-PTX group showed higher scores than the IPC-IR-PTX group, in accordance with the hypothesis of a favorable effect of IPC alone or in association with PTX. Additionally, IPC-IR-SS had a higher damage score than the IPC-IR-PTX. The villi height and crypt depth were similar in all groups. The villi height in the IR-SS was significantly lower. Conclusion: Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury. However, they do not have a synergistic effect when applied together.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502017000700559&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000700559&lng=en&nrm=iso
Starting Page	559
Ending Page	567
Page Count	9
File Format	PDF
ISSN	01028650
DOI	10.1590/s0102-865020170070000007
Journal	Acta Cirurgica Brasileira
Issue Number	7
Volume Number	32
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2017-07-01
Access Restriction	Open
Subject Keyword	Ischemic Preconditioning Pentoxifylline Ischemia Reperfusion Injury Intestines Rats
Content Type	Text
Resource Type	Article
Subject	Surgery

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