NDLI: Biodistribution of the radiophamarceutical sodium pertechnetate (Na99mTcO4) after massive small bowel resection in rats

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Chacon, Dâmaso de Araújo Araújo-Filho, Irami Villarim-Neto, Arthur Rêgo, Amália Cínthia Meneses Azevedo, Ítalo Medeiros Bernardo-Filho, Mário Brandão-Neto, José Medeiros, Aldo Cunha
Abstract	PURPOSE: To evaluate the biodistribution of sodium pertecnetate (Na99mTcO4) in organs and tissues, the morphometry of remnant intestinal mucosa and ponderal evolution in rats subjected to massive resection of the small intestine. METHODS: Twenty-one Wistar rats were randomly divided into three groups of 7 animals each. The short bowel (SB) group was subjected to massive resection of the small intestine; the control group (C) rats were not operated on, and soft intestinal handling was performed in sham rats. The animals were weighed weekly. On the 30th postoperative day, 0.l mL of Na99mTcO4, with mean activity of 0.66 MBq was injected intravenously into the orbital plexus. After 30 minutes, the rats were killed with an overdose of anesthetic, and fragments of the liver, spleen, pancreas, stomach, duodenum, small intestine, thyroid, lung, heart, kidney, bladder, muscle, femur and brain were harvested. The biopsies were washed with 0.9% NaCl.,The radioactivity was counted using Gama Counter WizardTM 1470, PerkinElmer. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated. Biopsies of the remaining jejunum were analysed by HE staining to obtain mucosal thickness. Analysis of variance (ANOVA) and the Tukey test for multiple comparisons were used, considering p<0.05 as significant. RESULTS: There were no significant differences in %ATI/g of the Na99mTcO4 in the organs of the groups studied (p>0.05). An increase in the weight of the SB rats was observed after the second postoperative week. The jejunal mucosal thickness of the SB rats was significantly greater than that of C and sham rats (p<0.05). CONCLUSION: In rats with experimentally-produced short bowel syndrome, an adaptive response by the intestinal mucosa reduced weight loss. The biodistribution of Na99mTcO4 was not affected by massive intestinal resection, suggesting that short bowel syndrome is not the cause of misleading interpretation, if an examination using this radiopharmaceutical is indicated.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502007000600003&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000600003&lng=en&nrm=iso
Starting Page	430
Ending Page	435
Page Count	6
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502007000600003
Journal	Acta Cirurgica Brasileira
Issue Number	6
Volume Number	22
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2007-12-01
Publisher Institution	UFRN Postgraduate Program in Health Sciences UFRN Scientific Initiation Program UFRN Department of Surgery UERJ Biophysics and Biometry Department
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Short Bowel Syndrome Sodium Pertechnetate Tc 99m Pharmacokinetics Síndrome do Intestino Curto Pertecnetato Tc99m de Sódio Farmacocinética Ratos
Alternative Title	Biodistribuição do radiofármaco pertecnetato de sódio (Na99mTcO4) em ratos submetidos a ressecção extensa de intestino delgado
Content Type	Text
Resource Type	Article
Subject	Surgery

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