NDLI: An experimental model for the study of drug effects on cutaneous healing

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Chiquetti Júnior, Antonio Rodrigues, Marco Aurélio de Freitas Delfino, Vinicius Daher Alvares
Abstract	PURPOSE: Immunosuppressive agents are known to interfere with the healing of surgical wounds. The increasing use of these drugs warrants a better understanding of their effects on wound healing. The aim of this study was to develop an experimental model that would allow for a reliable and rapid assessment of drug effects on cutaneous wound healing. METHODS: Thirty syngeneic Lewis rats underwent surgical incision on their dorsal region, in the presence or absence of a three-week regimen of immunosuppressant drug therapy (i.e., cyclosporin, azathioprine, and prednisone). Surgical site tissue was collected at intervals over 21 days after surgery and analyzed for cell number and collagen fiber content. Both of these quantitative assessments were performed using digital image capture with the Image Pro Plus 4.5 software. RESULTS: Computerized histomorphometric analyses revealed an apparent inhibition of cellular responses and collagen fiber production in drug-treated animals compared to control animals. CONCLUSION: The experimental model was reproducible, easy to perform, and allowed for quantitative histological evaluations. It may be useful for the study of surgical healing in the presence of other drug classes.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502007000400014&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400014&lng=en&nrm=iso
Starting Page	317
Ending Page	321
Page Count	5
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502007000400014
Journal	Acta Cirurgica Brasileira
Issue Number	4
Volume Number	22
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2007-08-01
Publisher Institution	UEL Department of Surgery Division of Plastic Surgery UEL Department of Surgery Division of Urology UEL Department of Internal Medicine Division of Nephrology
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Animal Experimentation Immunosuppression Wound Healing Rats Experimentação Animal Imunossupressão Cicatrização de Feridas Ratos
Alternative Title	Modelo experimental para o estudo de efeitos de drogas sobre a cicatrização cutânea
Content Type	Text
Resource Type	Article
Subject	Surgery

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