NDLI: Impact of propofol on renal ischemia/reperfusion endoplasmic reticulum stress

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Su, Mengqin Ren, Sueng Zhong, Wei Han, Xueping
Abstract	Abstract Purpose: To investigate the protective mechanisms of propofol (Pro) on renal ischemia/reperfusion (I/R) injury by studying its impact on renal I/R endoplasmic reticulum stress. Methods: Eighteen male Sprague-Dawley rats (SD rats) were randomly divided into three groups: the I/R group, the Pro pretreatment group, and the control group, and corresponding treatments were performed. The levels of serum creatinine (Cr) and blood urea nitrogen (BUN) of each group were detected. The expression levels of CCAAT-enhancer-binding protein (C/EBP) homology protein (CHOP) and caspase-12 protein within renal tissue samples were detected by western blot. Results: The periodic acid-Schiff (PAS) staining was performed to observe the morphological changes within the renal tissues, and the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay was performed to detect the presence of renal apoptosis. The Pro pretreatment significantly reduced the serum Cr and BUN levels, as well as the expressions levels of CHOP and caspase-12 protein inside the kidney of I/R rats, improving renal pathological injury and reducing the I/R-induced renal apoptosis. Conclusion: Propofol could downregulate the expression of stress-apoptotic proteins CHOP and caspase-12 in the endoplasmic reticulum, thus reducing renal I/R injury.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502017000700533&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000700533&lng=en&nrm=iso
Starting Page	533
Ending Page	539
Page Count	7
File Format	PDF
ISSN	01028650
DOI	10.1590/s0102-865020170070000004
Journal	Acta Cirurgica Brasileira
Issue Number	7
Volume Number	32
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2017-07-01
Access Restriction	Open
Subject Keyword	Endoplasmic Reticulum Stress Reperfusion Injury Propofol Kidney Rats
Content Type	Text
Resource Type	Article
Subject	Surgery

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