NDLI: Experimental study of peripheral-blood pro-surfactant protein B for screening non-small cell lung cancer

Content Provider	Scientific Electronic Library Online (SciELO)
Author	He, Yong Jiang, Zhenjie Tong, Fengzhi Li, Mingwu Yin, Xingru Hu, Shixin Wang, Linlin
Abstract	Abstract Purpose: To evaluate the possibility of using peripheral-blood presurfactant protein B (Pro-SFTPB) for screening non-small cell lung cancer (NSCLC). Methods: A total of 873 healthy volunteers and 165 lung cancer patients hospitalized in the Fifth People’s Hospital of Dalian were tested Pro-SFTPB once every half year from January 2014 to September 2015. The healthy volunteers were also conducted spiral computed tomography (CT) examination once every year. The data were then com-pared and statistically analyzed. Results: The positive expression rate of Pro-SFTPB in NSCLC was significantly higher than that in healthy volunteers, and significantly higher in lung adenocarcinoma than in squamous cell carcinoma; additionally, the expression rate was increased with the in-crease of smoking index, and the intergroup differences showed statistical signifi-cance (p≤0.05). The positive rate of newly diagnosed lung cancer was 29.55%, higher than healthy volunteers (22.34%), but there was no significant difference (p>0.05). Conclusion: Pro-SFTPB is over expressed in non-small cell lung cancer, especially in lung adeno-carcinoma, but it can’t be used as a clinical screening tool for lung cancer.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502017000700568&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000700568&lng=en&nrm=iso
Starting Page	568
Ending Page	575
Page Count	8
File Format	PDF
ISSN	01028650
DOI	10.1590/s0102-865020170070000008
Journal	Acta Cirurgica Brasileira
Issue Number	7
Volume Number	32
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2017-07-01
Access Restriction	Open
Subject Keyword	Non-Small Cell Lung Cancer Lung Neoplasms Mass Screening
Content Type	Text
Resource Type	Article
Subject	Surgery

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