NDLI: Role of the vitamin C in diethylnitrosamine-induced esophageal cancer in Wistar rats

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Ramos, Almino Cardoso Araujo, Marina Rachel Lopes, Luiz Roberto Andreollo, Nelson Adami
Abstract	PURPOSE: To evaluate the inhibitory effect of vitamin C on the experimental esophageal carcinogenesis induced by diethylnitrosamine (NDEA). METHODS: Sixty Wistar male rats aged three months, with mean weight of 210 g were employed in the study and were divided into four different groups according to the drinking drugs: group I - controls: only water, seven days a week; group II - only vitamin C, seven days a week; group III - NDEA, three days a week and water during the other four days; group IV - NDEA, three days a week and vitamin C during the other four days; group V - NDEA together with vitamin C three days a week, and only water during the other four days and group VI - NDEA together with vitamin C three days a week and vitamin C during the other four days. The dosages of NDEA were: - 10 mg. / Kg / day and vitamin C - 200 mg / animal / day, dissolved in drinking water. The animals were observed during 180 days and after that each one was sacrificed and its esophagus and the stomach were removed together and macro and microscopically analyzed to identify any tumors. RESULTS: The largest number of tumors was observed in the group III: 48 macroscopic lesions (4.8 lesions per animal) and 23 microscopic lesions (2.3 lesions per animal). The groups that received vitamin C (groups IV, V and VI) showed smaller number of tumors: group V - 0.5 macroscopic lesions and 0.3 microscopic lesions per animal and group VI - 0.1 macroscopic lesions and 0.1 microscopic lesions per animal. The incidence of tumors in the groups V and VI showed statistical significance (p<0.05), when compared to the other groups. CONCLUSION: The vitamin C administered together with diethylnitrosamine showed an inhibitory effect on the experimental esophageal carcinogenesis in Wistar rats.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502009000300004&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000300004&lng=en&nrm=iso
Starting Page	183
Ending Page	188
Page Count	6
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502009000300004
Journal	Acta Cirurgica Brasileira
Issue Number	3
Volume Number	24
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2009-06-01
Publisher Institution	UNICAMP School of Medical Sciences UNICAMP Laboratory of Enzymology and Experimental Carcinogenesis UNICAMP Department of Surgery Digestive Disease Division
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Esophageal Neoplasms Diethylnitrosamine Ascorbic Acid Rats Neoplasias Esofágicas Dietilnitrosamina Ácido Ascórbico Ratos
Alternative Title	O efeito inibidor da vitamina C na carcinogênese esofágica induzida pela dietilnitrosamina em ratos Wistar
Content Type	Text
Resource Type	Article
Subject	Surgery

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