NDLI: Sedative and clinical effects of the pharmacopuncture with xylazine in dogs

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Cassu, Renata Navarro Melchert, Alessandra Canoa, Jiancarlo Tortoza Bignelli Martins, Paula Denise de Oliveira
Abstract	PURPOSE: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs.METHODS: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg-1 of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint. Heart rate, cardiac rhythm (ECG), systolic arterial blood pressure (SABP), respiratory rate (RR), rectal temperature (RT), blood glucose concentration, degree of sedation and adverse effects were evaluated.RESULTS: Sedative effect was observed in both groups. The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group. Cardiovascular established was observed in X-Yintang group, while marked reduction in the HR and increased incidence of ECG abnormalities were detected in X-IM. In both treatment groups, minimal changes were observed in relation to SABP, RR, RT and blood glucose. High incidence (66%) of vomiting was observed in X-IM, while this adverse effect was absent in X-Yintang.CONCLUSION: Pharmacopuncture with xylazine induced clinically relevant sedative effects in dogs, with the advantage of reduction of undesirable side effects associated with α2-agonists, including bradycardia, cardiac arrhythmias, and emesis.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502014000100047&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100047&lng=en&nrm=iso
Starting Page	47
Ending Page	52
Page Count	6
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502014000100007
Journal	Acta Cirurgica Brasileira
Issue Number	1
Volume Number	29
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2014-01-01
Access Restriction	Open
Subject Keyword	Acupuncture Sedation Anxiolytic Agents Xylazine Dogs
Content Type	Text
Resource Type	Article
Subject	Surgery

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