NDLI: Effects of insulin-like growth factor-1 on random pattern skin flap survival in rats

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Haktanır, Nurten Turhan Yılmaz, Güray Bozkurt, Mehmet Fatih Demir, Yavuz
Abstract	ABSTRACT PURPOSE: To investigate the effects of pharmacological delay with insulin-like growth factor-1 (IGF-1) on skin flap survival. METHODS: Thirty Sprague-Dawley rats were submitted to dorsal skin flap (3x9 cm). Seven days before the surgery, the animals were subdivided into three groups of 10 rats. In group 1 (controls), no injection was done. Seven days before the elevation, saline had been injected to the marked skin flap area in group 2 (sham group), and group 3 (experimental group) underwent a pharmacological delay with subcutaneous IGF-1 injections. On the seventh postoperative day, flap area was analyzed for survival. Tissue samples were obtained for histological and biochemical evaluations. RESULTS: Survival rates were 43.55 ± 16%, 21.40 ± 8%, and 43.12 ± 14% in groups 1, 2, and 3, respectively. Differences between group 2 and other groups were statistically significant. No significant difference was detected between all three groups for tissue or plasma vascular endothelial growth factor (VEGF) levels. There was no significant histological difference between groups. CONCLUSION: Although a single injection of insulin-like growth factor-1 (IGF-1) did not significantly increase flap survival, its wound healing features are still encouraging and further meticulously planned studies, especially with repeated applications or controlled-release methods, and combinations with binding protein are required.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502016000800513&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000800513&lng=en&nrm=iso
Starting Page	513
Ending Page	519
Page Count	7
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-865020160080000003
Journal	Acta Cirurgica Brasileira
Issue Number	8
Volume Number	31
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2016-08-01
Access Restriction	Open
Subject Keyword	Insulin-Like Growth Factor I Surgical Flaps Survival Skin Rats
Content Type	Text
Resource Type	Article
Subject	Surgery

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