NDLI: Liver cirrhosis and hepatic stellate cells

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Brandão, Daniel Ferracioli Ramalho, Leandra Naira Zambelli Ramalho, Fernando Silva Zucoloto, Sérgio Martinelli, Ana de Lourdes Candolo Castro e Silva, Orlando de
Abstract	The cirrhosis represents the final stage of several chronic hepatic diseases and it is characterized by the presence of fibrosis and morphologic conversion from the normal hepatic architecture into structurally abnormal nodules. In the evolution of the disease there is loss of the normal vascular relationship and portal hypertension. There are also regenerative hepatocelular alterations that become more prominent with the progression of the disease. The liver transplantation continues to be the only therapeutic option in cases of disease in terminal phase. The hepatic stellate cells (HSC) are perisinusoidal cells that store vitamin A and produce growth factors, citocins, prostaglandins and other bioactive substances. They can suffer an activation process that convert them to cells with a phenotype similar to myofibroblasts. When activated, they present increased capacity of proliferation, mobility, contractility and synthesis of collagen and other components of extracelular matrix. They possess cytoplasmic processes adhered to sinusoids and can affect the sinusoidal blood flow. HSC are important in pathogenesis of fibrosis and portal hypertension.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502006000700013&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000700013&lng=en&nrm=iso
Starting Page	54
Ending Page	57
Page Count	4
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502006000700013
Journal	Acta Cirurgica Brasileira
Volume Number	21
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2006-01-01
Publisher Institution	USP FMRP Department of Pathology USP FMRP Department of Surgery and Anatomy USP FMRP Department of Medicine
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Liver Stellate Cells Hepatic Fibrosis Hepatic Cirrhosis Perisinusoidal Cells Portal Hypertension Fígado Células Estreladas Fibrose Hepática Cirrose Hepática Células Peri-sinusoidais Hipertensão Portal
Alternative Title	Cirrose hepática e células estreladas do figado
Content Type	Text
Resource Type	Article
Subject	Surgery

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