NDLI: Effect of different periods of hyperbaric oxygen on ischemia-reperfusion injury of rat small bowel

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Bertoletto, Paulo Roberto Chaves, José Carlos Fagundes, Anna Tereza Negrini Simões, Ricardo Santos Oshima, Celina Tizuko Fujiyama Simões, Manuel de Jesus Fagundes, Djalma José
Abstract	PURPOSE: To determine whether hyperbaric oxygen (HBO) could effectively protect the small intestine mucosa against an ischemic insult, according to different periods of application. METHODS: The gut of 32 male rats was subjected to 60-min ischemia (clamping the mesenteric artery and vein); After they were further reperfused upon clamp opening during 60 min. Animal groups were as follows. GII = placed on HBO during the ischemia period; GIII = placed on HBO during reperfusion; GIV = treated with HBO throughout the ischemia-reperfusion period. Some animals (GI) did not receive HBO treatment at all and served as reference of ischemia-reperfusion injury (IR). HBO was carried out in a cylindrical acrylic chamber (2.0 ATA). Samples of small bowel were prepared for H.E staining for histological evaluations. RESULTS: The histological injury of mucosa was significantly less when HBO was administered during the ischemia period (17.6 ± 0.6) as compared with the IR (21.3 ± 1.8). HBO was not effective when applied during reperfusion (23.1 ± 2.1) or during the ischemia plus reperfusion period (18.7 ± 1.9). The thickness of the mucosa was preserved by HBO in ischemia (327.50 ± 30.23 µm) in comparison with the IR (172.79 ± 5.95 µm). In the periods of reperfusion (162.50 ± 6.05 µm) and ischemia plus reperfusion (296.49 ± 20.01 µm) the mucosa revealed a structural injury. CONCLUSION: Hyperbaric oxygen affects the ischemic insult of small bowel, being the favorable effect obtained when hyperbaric oxygen was administered early in the ischemic period.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502008000100003&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000100003&lng=en&nrm=iso
Starting Page	11
Ending Page	15
Page Count	5
File Format	PDF
ISSN	01028650
DOI	10.1590/S0102-86502008000100003
Journal	Acta Cirurgica Brasileira
Issue Number	1
Volume Number	23
Language	English
Publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publisher Date	2008-02-01
Publisher Institution	University of Grande Dourados Santo Amaro University Medical School Federal University of São Paulo Medical School UNIFESP Molecular Pathology Division, Department of Pathology UNIFESP Department of Morphology Head of Histology and Structural Biology Division UNIFESP Department of Surgery Surgery Division of Operative Technique and Experimental Surgery
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Hyperbaric Oxygenation Ischemia Intestine Small Rats Oxigenação Hiperbárica Isquemia Intestino Delgado Ratos
Alternative Title	Efeitos de diferentes períodos de oxigenação hiperbárica na lesão de isquemia e reperfusão de intestino delgado de ratos
Content Type	Text
Resource Type	Article
Subject	Surgery

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