NDLI: White Matter Integrity Analysis along Cingulum Paths in Mild Cognitive Impairment

Content Provider	IEEE Xplore Digital Library
Author	Xuwei Liang Jun Zhang
Copyright Year	2008
Description	Author affiliation: Dept. of Comput. Sci., Univ. of Kentucky, Lexington, KY (Xuwei Liang; Jun Zhang)
Abstract	We present a new analysis scheme to measure regional micro structural white matter (WM) changes along the major cingulum fiber bundles which may not be effectively performed by existing methods due to its curved geospatial feature. The primary advantages of the technique lie in the diffusion tensor imaging tractography and geodesic distance mapping. The volumetric major cingulum is represented by a reconstructed fiber bundle. Quantitative analysis of regional micro structural WM alterations is based on the geodesic distance mapping, which allows cross-subject evaluation of diffusion properties by establishing correspondences through reparameterizing the space of reconstructed fiber bundle as a function of geodesic distance. Evaluation of the technique explores regional fractional anisotropy degradations along the left cingulum path in amnestic mild cognitive impairment subjects. Our experimental results indicate that this approach is effective and may provide a more sensitive alternative to examining the WM integrity of brain neuronal connectivity.
Starting Page	510
Ending Page	513
File Size	418412
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.124
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Degradation Temporal lobe Anisotropic magnetoresistance Image analysis Magnetic resonance imaging Performance analysis Level measurement Geophysics computing Image reconstruction Diffusion tensor imaging
Content Type	Text
Resource Type	Article

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