NDLI: Alginate-Templated Microcapsules Carrying Heparin via Layer-by-Layer Self-Assembly

Content Provider	IEEE Xplore Digital Library
Author	Juan Li Xinrong Liu Baoqing Zhu Yingya Shao Dongxu Zhao Xinlin Yang
Copyright Year	2008
Description	Author affiliation: Sch. of Life Sci. & Technol., Beijing Inst. of Technol., Beijing (Juan Li; Xinrong Liu; Baoqing Zhu; Yingya Shao; Dongxu Zhao; Xinlin Yang)
Abstract	Electrostatic layer-by-layer self-assembly is a simple and effective approach to carry macromolecules into microscale carriers. Calcium-cross-linked alginate hydrogel microspheres were fabricated by an emulsification technique and then used as negatively charged templates for polyelectrolyte multilayer coatings to entrap heparin. The polycation was poly (allylamine hydrochloride) (PAH), while the polyanion was heparin, an anticoagulant to prevent the clotting of blood. The microcapsule was formed via coating $\{PAH/heparin\}_{3}$ on $Ca^{2+}-cross-linked$ alginate hydrogel. The retention of alginate in $\{PAH/heparin\}_{3}$ microcapsule was confirmed by fluorescence inverted microscopy and confocal laser scanning microscopy. The assembly of polyelectrolyte layers on alginate microspheres was monitored by Zeta Potential Analyzer. The concentration of heparin was detected by HPLC with IR-detector and organic acid column. It was found that heparin could be entrapped in the microcapsules in high efficiency, providing a useful delivery system which would be found potential application in antagonizing thrombosis.
Starting Page	1420
Ending Page	1423
File Size	815768
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.684
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Self-assembly Microscopy Coagulation Fluorescence Nonhomogeneous media Coatings Electrostatics Blood Assembly Monitoring
Content Type	Text
Resource Type	Article

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