NDLI: Characterization and the Immune Regulation Activities in Vitro of Se-GL-P, an Antioxidant Selenium-Containing Protein from Se-Enriched Ganoderma Lucidum Mushroom

Content Provider	IEEE Xplore Digital Library
Author	Ming Du; Lanwei Zhang Xiaosong Hu Guanghua Zhao
Copyright Year	2008
Description	Author affiliation: Coll. of Food Sci. & Eng., Harbin Inst. of Technol., Harbin (Ming Du;; Lanwei Zhang)
Abstract	Our research group has purified an antioxidant selenium-containing protein (Se-GL-P) from Se-enriched Ganoderma Lucidum (Se-GL), its characteristics has been determined partly. In this study, the characteristics of Se-GL-P were identified further, in which the contents of selenocysteine (Se-Cys) and selenomethionine (Se-Met), isoelectric point (pi), and peptide mass fingerprint (PMF) were involved. Moreover, in vitro, the effects on multiplication of T and B lymphocyte cell and killing activity of NK cell were determined by method of MTS. The effect on secretion of TNF-alpha was determined by method of ELISA. Results showed that Se-GL-P was a kind of new selenium-containing protein proved by method of peptide mass fingerprint. 31.275 % of Selenium in total selenium amino acids was in form of Se-Cys, and 68.725% of that was in form of Se- Met. All groups with different doses of Se-GL-P could promote the multiplication of T and B lymphocyte cell of mouse as well as promoting the killing activity of NK cell. However, Se-GL-P had no better effect on TNF-alpha secretion by macrophages in mouse. At the same concentration, the immune regulation activity of Se-GL- P was higher than crude protein from Se-GL (SeGLPr). The immune regulation activity of the former was almost 1.5 times of the latter. Consequently, the results indicated that the Se-GL-P could be studied further, as a kind of bioactivity component with high immune regulation activity.
Starting Page	156
Ending Page	162
File Size	495469
Page Count	7
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.44
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protein engineering Peptides Humans Fingerprint recognition Fluids and secretions Amino acids Educational institutions Mice In vitro Immune system
Content Type	Text
Resource Type	Article

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