NDLI: Expression Analysis of Signal Transducer and Activator of Transcription 2 (stat2) Gene in Esophageal, Gastric and Lung Cancer Tissues

Content Provider	IEEE Xplore Digital Library
Author	Guang Gao Huiling Wu Yan Wu Wenbing Wang
Copyright Year	2008
Description	Author affiliation: Inst. of life Sci., Jiangsu Univ., Zhenjiang (Guang Gao; Huiling Wu; Yan Wu; Wenbing Wang)
Abstract	To further investigate the molecular mechanism of esophageal carcinogenesis, screen out and validate the genes expressed differently in esophageal cancer. mRNA differential display (DD-PCR) was employed to search differently expressed fragments, some of which were cloned and sequenced. By homology analysis in GenBank, corresponding homologous genes of those fragments were found. The corresponding genes of those differently expressed fragments were validated by Real-time quantitative PCR. By DD-PCR, one EST was identified to be Homo sapiens signal transducer and activator of transcription 2 (stat2) gene. The mRNA analysis result by real-time quantitative PCR showed that the expression level of stat2 gene in esophageal cancer (n=16, p<0.05), gastric cancer (n=12, p<0.05) and lung cancer tissues (n=16, p<0.05) were significantly higher than that in normal tissues. The ORF of stat2 gene was 2556 base pair long and encodes 852 amino acids. The molecular weight was about 97.9 KD. The over-expression of stat2 gene in esophageal cancer, gastric cancer and lung cancer may indicate an important role in these carcinogenesis.
Starting Page	466
Ending Page	469
File Size	152560
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.113
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Transducers Lungs RNA DNA Cloning Displays Signal analysis Esophagus Cancer Biological materials
Content Type	Text
Resource Type	Article

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