NDLI: Ab initio Studies on the Carcinogenic Mechanism of the Derivatives of 3,5-Dimethyl-Nitrosopiperazine

Content Provider	IEEE Xplore Digital Library
Author	Ting-ting Liu Li-jiao Zhao Ru-gang Zhong
Copyright Year	2008
Description	Author affiliation: Coll. of Life Sci. & Bioeng., Beijing Univ. of Technol., Beijing (Ting-ting Liu; Li-jiao Zhao; Ru-gang Zhong)
Abstract	3,5-Dimethyl-nitrosopiperazine (DMNP) is a kind of cyclic nitrosamine which was recognized as environment carcinogens. The carcinogenic potency of DMNP was observed to be different when their N atom was substituted with different groups. This distinction in the metabolic activation of alpha- and gamma-position was reported to contribute to their distinct carcinogenicity. In this work, ab initio computations were carried out to study the carcinogenic mechanism of alpha- and gamma-positions of DMNP and its derivatives. The results showed that the increase of the gamma-position activity induced the decline of the carcinogenic potency. However, the influence of the alpha-position activity was ambivalent, the carcinogenic potency can be reduced either too high or too low activity on alpha-position. This study of the metabolic processes of the alpha- and gamma-positions provided a theoretical evidence for the carcinogenic mechanism of cyclic nitrosamines.
Starting Page	951
Ending Page	954
File Size	292602
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.233
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vivo Chemistry DNA Liver Educational institutions Biochemistry Pattern recognition Biomedical engineering Electrons Esophagus
Content Type	Text
Resource Type	Article

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