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Auchus, “Diffusion tensor imaging of normal-appearing white matter in mild cognitive impairment and early Alzheimer disease: preliminary evidence of axonal degeneration in the temporal lobe (1943)
| Content Provider | CiteSeerX |
|---|---|
| Author | Huang, J. Friedland, R. P. Auchus, A. P. |
| Abstract | BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) is a sensitive technique for studying cerebral white matter. We used DTI to characterize microstructural white matter changes and their associations with cognitive dysfunction in Alzheimer disease (AD) and mild cognitive impairment (MCI). MATERIALS AND METHODS: We studied elderly subjects with mild AD (n 6), MCI (n 11), or normal cognition (n 8). A standardized clinical and neuropsychological evaluation was conducted on each subject. DTI images were acquired, and fractional anisotropy (FA), axial diffusivity (DA), and radial diffusivity (DR) of normal-appearing white matter (NAWM) in frontal, temporal, parietal, and occipital lobes were determined. These diffusion measurements were compared across the 3 groups, and significant differences were further examined for correlations with tests of cognitive function. RESULTS: Compared with normal controls, AD subjects demonstrated decreased FA and increased DR in the temporal, parietal, and frontal NAWM and decreased DA in temporal NAWM. MCI subjects also showed decreased FA and decreased DA in temporal NAWM, with decreased FA and increased DR in parietal NAWM. Diffusion measurements showed no differences in occipital NAWM. Across all subjects, temporal lobe FA and DR correlated with episodic memory, frontal FA and DR correlated with |
| File Format | |
| Journal | American Journal of Neuroradiology |
| Language | English |
| Publisher Date | 1943-01-01 |
| Access Restriction | Open |
| Subject Keyword | Normal-appearing White Matter Mild Cognitive Impairment Early Alzheimer Disease Axonal Degeneration Temporal Lobe Preliminary Evidence Decreased Fa Temporal Nawm Diffusion Measurement Significant Difference Axial Diffusivity Elderly Subject Occipital Nawm Microstructural White Matter Change Neuropsychological Evaluation Alzheimer Disease Dti Image Radial Diffusivity Temporal Lobe Fa Cognitive Function Frontal Fa Parietal Nawm Diffusion Tensor Imaging Episodic Memory Cognitive Dysfunction Frontal Nawm Normal Control Normal Cognition Sensitive Technique Ad Subject Occipital Lobe Cerebral White Matter Mild Ad Fractional Anisotropy |
| Content Type | Text |
| Resource Type | Article |
