NDLI: Bipolarity of the Saccharomyces Cerevisiae Genome

Content Provider	IEEE Xplore Digital Library
Author	Heath, A.P. Kavraki, L. Balazsi, G.
Copyright Year	2008
Description	Author affiliation: Dept. of Comput. Sci., Rice Univ., Houston, TX (Heath, A.P.; Kavraki, L.)
Abstract	Accumulating evidence indicates that eukaryotic genes tend to belong in two distinct categories that we will call class I and class II. Class I genes do not contain a TATA box in their promoter, and have low expression variability both at the single cell level (in constant environment) and at the population level (in changing environmental conditions). In contrast, class II genes contain a TATA box in their promoter, and tend to have pronounced expression variability both at the single cell level (in constant environment) and at the population level (in changing environmental conditions). Here we show that the positioning and regulation of class I and class II genes is strikingly different in the large-scale transcriptional regulatory (TR) network of S. cerevisiae. We also show that class I and class II genes differ dramatically in several properties, including gene expression variability at diverse time scales and population sizes, mutational variance, gene essentiality and subcellular localization. This dichotomy might indicate that evolution placed different genes in different locations within the cell and within the TR network, according to some fundamental principles that govern cellular information processing and survival in a changing environment.
Starting Page	330
Ending Page	333
File Size	215192
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.84
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Computer science Cellular networks Evolution (biology) Working environment noise Genomics Large-scale systems Gene expression Bioinformatics Stress
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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