NDLI: Identifying Critical Positions and Rules of Antigenic Drift for Influenza A/H3N2 Viruses

Content Provider	IEEE Xplore Digital Library
Author	Jhang-Wei Huang Chun-Chen Chen Jinn-Moon Yang
Copyright Year	2008
Description	Author affiliation: Inst. of Bioinf., Nat. Chiao Tung Univ., Hsinchu (Jhang-Wei Huang)
Abstract	Pathogenic avian and human influenza virus often cause disastrous damage to human society and economics. Understanding antigenic drift of influenza viruses is an emergent issue for prophylaxis and vaccine development. In this study, we identified antigenic critical amino acid positions on hemagglutinin (HA) gene and rules for predicting antigenic variants. The information gain (IG) is applied to calculate the degree of association between the position mutation and antigenic drift. An amino acid with high IG at a specific position implied that this position is highly correlated to antigenic type change. The decision tree is applied to build model and discover rules for predicting antigenic variants. The decision tree can identify amino acid mutation rules that lead to the antigenic drift. The predicting accuracy of this model is 91.2% which is better than related models. Most of these selected positions with high IG are located on epitope or surface on the HA structure. The position 145 with highest information gain could lead to antigenic cluster transition were verified. These results demonstrate that our approach is robust and is potential useful for vaccine development.
Starting Page	249
Ending Page	252
File Size	288924
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.65
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Pathogens Genetic mutations Influenza Humans Predictive models Amino acids Economic forecasting Vaccines Decision trees Viruses (medical)
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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