NDLI: C2H2 Zinc Finger Nucleotide Fluctuation

Content Provider	IEEE Xplore Digital Library
Author	Tremberger, G. Cheung, E. Subramaniam, R. Sullivan, R. Schneider, P. Flamholz, A. Lieberman, D. Cheung, T. Holden, T.
Copyright Year	2008
Description	Author affiliation: Queensborogh Community Coll., CUNY, Bayside, NY (Tremberger, G.; Cheung, E.)
Abstract	A C2H2 zinc finger nucleotide sequence can be expressed as a numerical sequence when each nucleotide is assigned its proton number. A resulting zinc finger numerical sequence could be investigated for its fractal dimension in terms of evolution, multiple finger structure flexibility, and 3-finger structure specificity. The ZNF714 sequence was found to have a fractal dimension higher than its evolutionary ancestor ZNF431, consistent with the recently reported evolutionary direction using traditional analysis. The ZNF91 sequence has 36 zinc fingers and their fractal dimensions form a Gaussian-like histogram, suggesting a maximal flexibility for capacity dimension. The $C_{p}G$ di-nucleotide percentage in the three zinc fingers of EGR1 is found to correlate with the fractal dimension while the five zinc fingers in ZFP91 separated into human-chimp and mouse-rat-dog groups. Extension of the fractal investigation to short genetic sequences is discussed.
Starting Page	943
Ending Page	946
File Size	199692
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.231
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protons Fluctuations Sequences Evolution (biology) Fingers Humans Genetics Fractals Mice Zinc
Content Type	Text
Resource Type	Article

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