NDLI: Investigation on Diurnal Variation and Gender Difference in Human Urine Using NMR-Based Metabonomics

Content Provider	IEEE Xplore Digital Library
Author	Xiaoxia Dai Qiqing Zhang Jiyang Dong Zhong Chen Changqin Liu Shuyu Yang
Copyright Year	2008
Description	Author affiliation: Res. Center of Biomed. Eng., Xiamen Univ., Xiamen (Xiaoxia Dai; Qiqing Zhang)
Abstract	$^{1}H$ NMR-based metabonomics has shown considerable potential as a means of rapidly detecting and characterizing a myriad of metabolic components. The $^{1}H$ NMR spectra obtained for human urine samples were visually inspected and analyzed using principal component analysis (PCA). Urine samples were collected eight times daily (8:00, 10:00, 12:00, 14:00,18:00, 20:00) from healthy volunteers with a standard diet and lifestyle for 2 consecutive days. Separation of urinary data according to time of sampling collection was achieved. The fluctuations of creatinine, citrate and observed between urine samples collected during the different time of day may be related to hormone levels. In addition, gender-difference was also investigated and the PCA score plots revealed several metabolites that were considered significant for distinguishing between male and female: creatinine, glycine and citrate. These results showed the value of metabonomic methods in the investigation of physiological variation and rhythms, and provided suggestions to collect significative metabonomics data in clinical studies.
Starting Page	2240
Ending Page	2243
File Size	228347
Page Count	4
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.891
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Spectroscopy Humans Biochemistry Nuclear magnetic resonance Pattern recognition Plasma temperature Principal component analysis Diseases Biomedical engineering
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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