NDLI: Association Study of 5-HT2A Receptor Gene Polymorphism with Persistent Somatoform Pain Disorder and the Efficacy of Fluoxetine

Content Provider	IEEE Xplore Digital Library
Author	Yanli Luo Wenyuan Wu Chunbo Li Mingyuan Zhang Ye Zhang Sanduo Jiang
Copyright Year	2008
Description	Author affiliation: Tongji Hosp., Dept. of Psychosomatics, Tongji Univ., Shanghai (Yanli Luo; Wenyuan Wu; Chunbo Li)
Abstract	To analyze the association between the 5- HT2A receptor gene polymorphism and persistent somatoform pain disorder in Chinese, and to investigate the relationship between the analgesic efficacy of fluoxetine and 5-HT2A receptor gene polymorphism. 51 patients with persistent somatoform pain disorder were administered with fluoxetine(20 mg/day) for 6 weeks. The response to fluoxetine was assessed by the Medical Outcomes Study Pain Measures (MOSPM). The patients were divided into two groups (responders and non-responders) according to the MOSPM response rate. The T102C polymorphism genotype and allele frequencies of 5-HT2A receptor gene in these 51 patients and 60 healthy controls were detected with PCR-RFLP technique. 1. No significant association was found between persistent somatoform pain disorder and 5-HT2A receptor gene T102C polymorphism. 2. In responders group, number of patients with C/C genotype and C allele frequency was significantly higher than that of non-responder group, while the frequency of T/T genotype and T allele was vice versa (p<0.05). It indicated that the T102C polymorphism of the 5- HT2A receptor gene was not significant factor associated with persistent somatoform pain disorder, but it may be one predictor of the analgesic efficacy of some SSRIs treatment.
Starting Page	399
Ending Page	401
File Size	93563
Page Count	3
File Format	PDF
ISBN	9781424417476
DOI	10.1109/ICBBE.2008.101
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Pain Hospitals Inhibitors Antidepressants Psychology Medical treatment Frequency Genetics Medical diagnostic imaging Diseases
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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