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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, X. J. Zheng, Y. H. Qiu, C. Bian, G. X. Jiang, N. Wen, S. H. Zhang, X. F. |
| Description | Country affiliation: China Author Affiliation: Jiang N ( Department of Pharmacy, Beijing Military Region, General Hospital, Beijing, China. jiangnan7757@sohu.com) |
| Abstract | Suppression subtractive hybridization was used to analyze differential expression of genes in rat peritoneal macrophages after granulocyte macrophage colony-stimulating factor treatment. We identified and cloned the mouse C10 analog gene in the rat, and named it as ccl6. The full-length cDNA of rat ccl6 was 467 bp, which contains a single-open reading frame and encodes 116 amino acid residues. Compared with other C-C chemokines, the rat ccl6 gene had an unusual four-exon genome structure instead of the typical three exons, it had the highest homology with murine ccl6. The rat ccl6 gene was localized on chromosome 10, where most of the C-C chemokine superfamily members are located. The recombinant rat C-C chemokine ligand 6 (CCL6) protein was expressed by the pGEX4T-1 plasmid in Escherichia coli BL21. The purified recombinant protein had bioactivity similar to that of mouse CCL6, which is a chemoattractant for macrophages and lymphocytes, but not for neutrophils. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2012-11-12 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Chemokines, Cc Genetics Sequence Homology, Nucleic Acid Amino Acid Sequence Animals Chemistry Isolation & Purification Chemotaxis Drug Effects Cloning, Molecular Electrophoresis, Polyacrylamide Gel Exons Hybridization, Genetic Introns Mice Molecular Sequence Data Neutrophils Cytology Phylogeny Recombinant Proteins Pharmacology Sequence Alignment Sequence Analysis, Dna Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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