NDLI: Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster.

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Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster.

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Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koksal, Pakize Muge Gürbüzel, Mehmet
Description	Country affiliation: Turkey Author Affiliation: Koksal PM ( Department of Biology, Faculty of Arts and Sciences, Erzincan University, 24100 Erzincan, Turkey.); Gürbüzel M ( Department of Biology, Faculty of Arts and Sciences, Erzincan University, 24100 Erzincan, Turkey. Electronic address: mehmetgurbuzel@hotmail.com.)
Abstract	The present study evaluated the mutagenic and recombinogenic effects of two commonly used anesthetic agents, ketamine and rocuronium bromide, in medicine using the wing somatic mutation and recombination test (SMART) in Drosophila. The standard (ST) cross and the high-bioactivation (HB) cross with high sensitivity to procarcinogens and promutagens were used. The SMART test is based on the loss of heterozygosity, which occurs via various mechanisms, such as chromosome loss and deletion, half-translocation, mitotic recombination, mutation, and non-disjunction. Genetic alterations occurring in the somatic cells of the wing's imaginal discs result in mutant clones in the wing blade. Three-day-old trans-heterozygous larvae with two recessive markers, multiple wing hairs (mwh) and flare (flr(3)), were treated with ketamine and rocuronium bromide. Analysis of the ST cross indicated that ketamine exhibited genotoxicity activity and that this activity was particularly dependent on homologous mitotic recombination at concentrations of 250 µg/ml and above. Rocuronium bromide did not exert mutagenic and/or recombinogenic effects. In the HB cross, ketamine at a concentration of 1000 µg/ml and rocuronium bromide at all concentrations, with the exception of 250 µg/ml (inconclusive), exerted genotoxic effects, which could also be associated with the increase in mitotic recombination.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Androstanols Toxicity Anesthetics Drosophila Melanogaster Drug Effects Ketamine Mutagens Animals Genetics Female Male Mutagenicity Tests Mutation Recombination, Genetic Wing Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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