NDLI: Monte Carlo simulation study of in-beam intra-treatment PET imaging for adaptive proton therapy

Content Provider	IEEE Xplore Digital Library
Author	Kai Lou Mirkovic, D. Xishan Sun Zhu, X.R. Clark, J. Yiping Shao
Copyright Year	2013
Description	Author affiliation: Dept. of Radiat. Phys., Univ. of Texas M.D. Anderson Cancer Center, Houston, TX, USA (Mirkovic, D.; Zhu, X.R.) \|\| Dept. of Electr. & Comput. Eng., Rice Univ., Houston, TX, USA (Clark, J.) \|\| Dept. of Imaging Phys., Univ. of Texas M.D. Anderson Cancer Center, Houston, TX, USA (Kai Lou; Xishan Sun; Yiping Shao)
Abstract	We conducted Monte Carlo simulations to investigate the feasibility of the proton beam-range verification with few beam spills before the start of treatment to provide rapid feedback for treatment plan verification and re-planning (if necessary) for improving the accuracy of treatment targeting: a potentially novel intra-treatment image-guided adaptive proton therapy. MCNPX package was used to generate the distributions of positron emitters in a uniform cylinder PMMA phantom irradiated by a collimated 180 MeV pristine proton beam. Two PET systems, a small dual-panel rotational PET and a stationary brain PET, with depth-of-interaction (DOI) measurement, were simulated with GATE for imaging. The images were reconstructed with list-mode MLEM algorithm using simulated coincidence data accumulated during- and post-irradiations. Positron activity-ranges were measured as a function of number of beam spills, total acquisition time, crystal cross-section size, crystal length, and the number of coincidence events. Results show that the accuracy of activity-range measurement is a function of data statistics but converging rapidly within few beam spills under simulated conditions; few spills can be sufficient to measure the activity-range within 1.0 mm from the final converged value; the number of spills can be further reduced if acquiring 30-60 sec post-irradiation data, which is still considered a rapid intra-treatment imaging. The accuracy and precision of activity-range measurement was also calculated as a function of count statistics under the simulated conditions, providing a general and very useful guideline to calculate the required statistics for an accurate intra-treatment “in-beam” activity-range measurement.
Starting Page	1
Ending Page	5
File Size	453155
Page Count	5
File Format	PDF
e-ISBN	9781479905348
DOI	10.1109/NSSMIC.2013.6829312
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-10-27
Publisher Place	South Korea
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Crystals Protons Positron emission tomography Accuracy Particle beams Positrons
Content Type	Text
Resource Type	Article

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