NDLI: $^{176}Lu$ effect on the minimum detectable activity limits for a dual head, LSO: Ce based, PET system

Content Provider	IEEE Xplore Digital Library
Author	Efthimiou, N. Loudos, G. Karakatsanis, N.A. Panayotakis, G.
Copyright Year	2013
Description	Author affiliation: Dept. of Med. Phys., Univ. of Patras, Rion, Greece (Efthimiou, N.; Panayotakis, G.) \|\| Dept. of Radiol., Johns Hopkins Univ., Baltimore, MD, USA (Karakatsanis, N.A.) \|\| Dept. of Biomed. Eng., Technol. Educ. Inst. of Athens, Athens, Greece (Loudos, G.)
Abstract	Novel molecular imaging applications increasingly involve studies were very low amount of radiotracer is injected into the subject. This is a challenging problem in terms of image quality, especially when intrinsic radioactivity from the detector is considered. LSO crystals contain $^{176}Lu,$ which spontaneously emits $b^{-}$ particles and γ photons which increase the statistical noise of the recorded events. Using a dual head PET prototype camera, a series of acquisitions was performed in order to investigate the effect of the energy window to the counting rate performance and the image quality and the minimum detectable activity. In addition, the experiments were simulated with GATE, and the results were validated over the experimental. The used activities ranged below 104kBq. The coincidence images were calculated using the focal plane tomography method. Very good agreement between experimental and simulated results was demonstrated and a well validated model of $^{176}Lu$ simulation is available. In addition the minimum detectable activity of the system was found to be approximately 13kBq, when a linear capillary source and a 450-650keV energy window were used. Using a wider energy window, 380-650keV, and a cylindrical water phantom with diameter (4cm) we observed a positive impact one image quality at low activities, in terms of SNR. Even thought the rise on the scattered photons was not negligible the positive impact on the simulated true events was considered as a the driving factor.
Starting Page	1
Ending Page	3
File Size	267081
Page Count	3
File Format	PDF
e-ISBN	9781479905348
DOI	10.1109/NSSMIC.2013.6829191
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-10-27
Publisher Place	South Korea
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Logic gates Signal to noise ratio Head Magnetic heads Cameras GATE LSO SNR minimum detectable activity dual head PET
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in