NDLI: A severe case of vasoplegic shock following metformin overdose successfully treated with methylene blue as a last line therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Winearls, James Graham, Rachel Erin Cartner, Michaela
Description	Author Affiliation: Graham RE ( Intensive Care Unit, Gold Coast University Hospital, Southport, Queensland, Australia.); Cartner M ( Intensive Care Unit, Gold Coast University Hospital, Southport, Queensland, Australia.); Winearls J ( Intensive Care Unit, Gold Coast University Hospital, Southport, Queensland, Australia.)
Abstract	A 44-year-old man presented to hospital 24 h after an intentional overdose of metformin and gliclazide. He had a critical metabolic acidosis on presentation with a pH of 6.88, and very rapidly deteriorated into distributive shock refractory to large volume fluid resuscitation and massive doses of vasopressors. We introduced a methylene blue infusion as a rescue therapy in an attempt to improve the patient's haemodynamics, which was successful. The patient made a full recovery with no long-term sequelae.
Volume Number	2015
e-ISSN	1757790X
Journal	BMJ Case Reports
Language	English
Publisher	BMJ Publishing Group Ltd.
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Drug Overdose Drug Therapy Metformin Administration & Dosage Methylene Blue Therapeutic Use Shock Vasoplegia Acidosis Etiology Adult Complications Fluid Therapy Gliclazide Humans Male Adverse Effects Vasoconstrictor Agents Case Reports Journal Article Multidisciplinary
Content Type	Text
Resource Type	Article

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A severe case of vasoplegic shock following metformin overdose successfully treated with methylene blue as a last line therapy.