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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Urita, Yoshihisa Sasaki, Yosuke Takeuchi, Taizo Furuya, Kenta |
| Description | Author Affiliation: Furuya K ( Department of General Medicine and Emergency Care, Toho University School of Medicine, Ota-Ku, Tokyo, Japan.); Sasaki Y ( Department of General Medicine and Emergency Care, Toho University School of Medicine, Ota-Ku, Tokyo, Japan.); Takeuchi T ( Department of General Medicine and Emergency Care, Toho University School of Medicine, Ota-Ku, Tokyo, Japan.); Urita Y ( Department of General Medicine and Emergency Care, Toho University School of Medicine, Ota-Ku, Tokyo, Japan.) |
| Abstract | Patients with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit various combinations of signs and symptoms including facial dysmorphism, thymus absence, hypoparathyroidism, cellular immunodeficiency and cardiac abnormalities caused by microdeletion of chromosome 22q11.2. Most cases are diagnosed during post-natal cardiac evaluation, though some are diagnosed at later stages. We report the case of a 39-year-old man with 22q11.2DS presenting with seizure due to tardily manifested hypocalcaemia and anxiety disorder. Our experience suggests that 22q11.2DS patients lacking fatal or well-recognised manifestations such as cardiac defects, immunodeficiency and facial dysmorphism tend to survive without medical attention, and are therefore overlooked. Recognition of the age-related variance of the manifestations, and specifically of tardily manifested hypocalcaemia and psychiatric or developmental disorders as manifestations of 22q11.2DS in adulthood, is important for diagnosis and can also help us provide appropriate medical and psychosocial support for newly diagnosed 22q11.2DS patients in adolescence or adulthood and their families. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | DiGeorge Syndrome Diagnosis Hypocalcemia Genetics Muscle Cramp Seizures Adult Asian Continental Ancestry Group Calcium Compounds Blood Genetic Testing Humans Complications Lactates Male Etiology Treatment Outcome Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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