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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lenglet, Sébastien Mach, François Montecucco, Fabrizio |
| Description | Country affiliation: Switzerland Author Affiliation: Lenglet S ( Division of Cardiology, Faculty of Medicine, Foundation for Medical Research, Geneva University Hospitals, Avenue de la Roseraie 64, 1211 Geneva 4, Switzerland.) |
| Abstract | Vasoplegic syndrome is a common complication of cardiopulmonary bypass, appearing with an incidence ranging between 5 and 25%. It is characterized by significant hypotension, high or normal cardiac output and low systemic vascular resistance. This syndrome is hypothesized to be caused by the inflammation-mediated dysregulation of endothelial homeostasis and subsequent endothelial dysfunction. In vasoplegic syndrome, the inhibition of the nitric oxide/cyclic guanosine monophosphate pathway with concomitant administration with traditional ionotropes may represent a promising therapeutic option. Methylene blue, an inhibitor of nitric oxide synthase and guanylate cyclase, may contribute to the improvement of refractory hypotension associated with endothelial dysfunction in vasoplegia. In this article, we will update evidence on the potential therapeutic use of methylene blue in vasoplegic syndrome. |
| File Format | HTM / HTML |
| ISSN | 14779072 |
| Issue Number | 12 |
| Volume Number | 9 |
| e-ISSN | 17448344 |
| Journal | Expert Review of Cardiovascular Therapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Cardiology Discipline Vascular Diseases Cardiopulmonary Bypass Adverse Effects Guanylate Cyclase Antagonists & Inhibitors Intraoperative Complications Drug Therapy Methylene Blue Therapeutic Use Nitric Oxide Synthase Postoperative Complications Vasoplegia Cardiac Surgical Procedures Cardiotonic Agents Administration & Dosage Drug Therapy, Combination Enzyme Inhibitors Humans Etiology Prevention & Control Salvage Therapy Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Cardiology and Cardiovascular Medicine |
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