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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wilson, N. J. Currie, P. F. Mcglacken-byrne, S. M. Parry, H. M. |
| Description | Author Affiliation: McGlacken-Byrne SM ( Green Lane Paediatric Cardiac and Congenital Services, Starship Children's Health, Auckland District Health Board, Auckland, New Zealand.); Parry HM ( Cardiology Department, Medical Annex, Perth Royal Infirmary, NHS Tayside, Perth, UK.); Currie PF ( Cardiology Department, Medical Annex, Perth Royal Infirmary, NHS Tayside, Perth, UK.); Wilson NJ ( Green Lane Paediatric Cardiac and Congenital Services, Starship Children's Health, Auckland District Health Board, Auckland, New Zealand.) |
| Abstract | Our patient is an 18-year-old Caucasian woman from the UK who developed severe mitral stenosis on a history of childhood acute rheumatic fever (ARF) and rheumatic heart disease (RHD). She had been reporting of her oral penicillin secondary prophylaxis regimen since diagnosis. At the age of 15â years, a new murmur was discovered during routine cardiac follow-up. An echocardiogram confirmed moderate-severe mitral stenosis. One year later, her exercise tolerance significantly deteriorated and she subsequently underwent balloon valvuloplasty of her mitral valve to good effect. Our case emphasises the evidence base supporting the use of monthly intramuscular penicillin injection to prevent ARF recurrence and RHD progression; it also emphasises the reduced efficacy of oral penicillin prophylaxis in this context. It particularly resonates with regions of low rheumatic fever endemicity. The long-term cardiac sequelae of ARF can be devastating; prescribing the most effective secondary prophylaxis regimen is essential. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anti-Bacterial Agents Administration & Dosage Mitral Valve Stenosis Prevention & Control Penicillins Rheumatic Fever Complications Rheumatic Heart Disease Administration, Oral Adolescent Disease Progression Female Humans Microbiology Treatment Failure Great Britain Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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