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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Van Marcke, Cédric Petit, Bénédicte Ledoux, Benjamin Seront, Emmanuel |
| Description | Author Affiliation: van Marcke C ( Department of Medical Oncology, Hopital de Jolimont, Haine-Saint-Paul, Belgium.); Ledoux B ( Department of Medical Oncology, Hopital de Jolimont, Haine-Saint-Paul, Belgium.); Petit B ( Department of Medical Oncology, Hopital de Jolimont, Haine-Saint-Paul, Belgium.); Seront E ( Department of Medical Oncology, Hopital de Jolimont, Haine-Saint-Paul, Belgium.) |
| Abstract | Tyrosine kinase inhibitors, represented by sunitinib, sorafenib, axitinib and pazopanib, are emerging molecules harbouring antitumoural efficacy in multiple neoplasia. We report the case of a 51-year-old woman with right thoracic sarcoma who developed fatal heart failure on pazopanib. The patient had no cardiovascular risk factor, except previous exposure to anthracycline, and her cardiac function was normally controlled before initiating the pazopanib. Despite a rapid tumour response, fatigue rapidly appeared, requiring treatment interruption 2 weeks after pazopanib introduction. After clinical improvement, the pazopanib was reintroduced at reduced dose; however, a few days later, our patient was admitted for worsening dyspnoea and fatigue. Pulmonary embolism was excluded as was pleuropericardial effusion. Brain natriuretic peptide was the only laboratory abnormality, and echocardiography revealed acute and severe heart failure. The patient died despite pazopanib arrest and inotropic support. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antineoplastic Agents Adverse Effects Heart Failure Chemically Induced Pyrimidines Sulfonamides Dyspnea Fatal Outcome Fatigue Female Humans Middle Aged Sarcoma, Synovial Drug Therapy Thoracic Neoplasms Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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