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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kitt, Jamie Irons, Robert Al-obaidi, Mohamed Missouris, Constantinos |
| Description | Author Affiliation: Kitt J ( Department of Cardiology, Frimley Health NHS Foundation Trust, Slough, UK.); Irons R ( Department of Geriatrics, Royal Berkshire Hospital, Reading, UK.); Al-Obaidi M ( Department of Cardiology, Frimley Health NHS Foundation Trust, Slough, UK.); Missouris C ( Department of Cardiology, Frimley Health NHS Foundation Trust, Slough, UK.) |
| Abstract | An 80-year-old woman with Alzheimer's dementia presented with diarrhoea, vomiting and worsening confusion following an increase in donepezil dose from 5 to 10â mg. The ECG revealed prolongation of QTc interval. Soon after admission, she became unresponsive with polymorphic ventricular tachycardia (VT). Cardiopulmonary resuscitation with a 200â J shock was successful in establishing cardiac output. Following the discontinuation of donepezil, the QTc interval normalised and no further arrhythmias were recorded. Treatment with anticholinesterase inhibitors may result in life-threatening VT. Vigilance is required for the identification of this condition in patients presenting with presyncope, syncope or seizures. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Alzheimer Disease Drug Therapy Indans Adverse Effects Long QT Syndrome Chemically Induced Nootropic Agents Piperidines Torsades De Pointes Aged, 80 And Over Cardiopulmonary Resuscitation Electrocardiography Female Humans Administration & Dosage Seizures Syncope Therapy Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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