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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bahl, Rahul Mohamedbhai, Hussein Puttick, Thomas |
| Description | Author Affiliation: Puttick T ( Department of General Surgery, Royal Berkshire NHS Hospital, Reading, Berkshire, UK.); Bahl R ( Department of General Surgery, Royal Berkshire NHS Hospital, Reading, Berkshire, UK.); Mohamedbhai H ( Department of General Surgery, Royal Berkshire NHS Hospital, Reading, Berkshire, UK.) |
| Abstract | An 80-year-old woman had the anticoagulant effect of dabigatran etexilate reversed using factor eight inhibitor bypassing activity (FEIBA) in order to facilitate emergency surgery for an incarcerated femoral hernia. She had atrial fibrillation was taking the anticoagulant for stroke prevention. That afternoon her international normalised ratio (INR) was 1.3 and activated partial thromboplastin time ratio (APPTr) was 2.17, having taken dabigatran that morning. 3000â units of FEIBA and 10â mg of vitamin K were administered and she was taken to theatre for emergency surgery. Surgery was successful, total blood loss was less than 100â mL and there were no complications. The following morning she had an INR of 1.1 and APPTr of 1.49. She made an uneventful postoperative recovery and was discharged home. There is a limited evidence base guiding practice in the clinical scenario described. The only controlled studies available are animal experiments. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antithrombins Adverse Effects Atrial Fibrillation Drug Therapy Blood Coagulation Factors Administration & Dosage Dabigatran Hernia, Femoral Surgery Postoperative Hemorrhage Prevention & Control Aged, 80 And Over Emergency Medicine Female Humans International Normalized Ratio Partial Thromboplastin Time Treatment Outcome Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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