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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Caliskan-kartal, Aysun Güner, Müberra Devrim Tuncbilek, Semra Akan, Burak |
| Description | Author Affiliation: Güner MD ( Department of Pharmacology, Ufuk University Medical School, Ankara, Turkey.); Tuncbilek S ( Department of Infectious Diseases and Clinical Microbiology, Ufuk University Medical School, Ankara, Turkey.); Akan B ( Department of Orthopaedics, Ufuk University Medical School, Ankara, Turkey.); Caliskan-Kartal A ( Department of Internal Medicine, Ufuk University Medical School, Ankara, Turkey.) |
| Abstract | We report two cases of hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (HSS/DRESS) syndrome following systemic and local (via antibiotic laden bone cement (ALBC)) exposures to vancomycin. Both cases developed symptoms 2-4â weeks after the initiation of treatment. They responded to systemic corticosteroid treatment and were cured completely. Various drug groups may cause HSS/DRESS syndrome, and vancomycin-related cases do not exceed 2-5% of the reported cases. Almost all of these cases developed the syndrome following systemic exposure to vancomycin. ALBC seems to be the safer antibiotic administration method, as systemic antibiotic levels did not reach a toxic threshold level. However, local administration may not always be sufficient for bone-related/joint-related infections; these infections may require systemic antibiotics as well. As HSS/DRESS syndrome can mimic infectious diseases, it must be considered during differential diagnosis before suspecting failure of treatment and initiation of a different antibiotic course. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anti-Bacterial Agents Adverse Effects Bone Cements Drug Hypersensitivity Syndrome Diagnosis Etiology Eosinophilia Chemically Induced Histamine Antagonists Administration & Dosage Vancomycin Adrenal Cortex Hormones Aged Drug Therapy Female Fever Humans Male Tachycardia Treatment Outcome Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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