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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lo, Tom Edward Ngo Lantion-ang, Frances Lina Andal, Zillien C. |
| Description | Author Affiliation: Lo TE ( Department of Medicine-Endocrinology, University of the Philippines-Philippine General Hospital, Manila, Philippines.); Andal ZC ( Department of Medicine-Hematology-Oncology, University of the Philippines-Philippine General Hospital, Manila, Philippines.); Lantion-Ang FL ( Section of Endocrinology, Diabetes and Metabolism Department of Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines.) |
| Abstract | Gynaecomastia is a benign condition characterised by enlargement of the male breast. Drug-induced gynaecomastia merits deep consideration as it may account for as many as 25% of all cases of gynaecomastia in adults. Although the mechanism is not fully clear, some mechanisms include oestrogen-like activities, stimulation of testicular production of oestrogens, inhibition of testosterone synthesis or blockade of androgen action. Anabolic steroids, in particular when used during the pubertal stage, may cause significant irreversible gynaecomastia. We report a case of 28-year-old Filipino man with persistent gynaecomastia from fluoxymesterone used for aplastic anaemia during his prepubertal stage. Hormonal work ups for gynaecomastia all turned out normal, thus isolating the drug as the cause. The patient was unable to undergo breast reconstruction surgery due to haematological contraindications, but eventually referred to psychiatry for counselling. This case will highlight the paradoxical effect of androgenic steroid used during childhood on male breast proliferation during puberty. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anabolic Agents Adverse Effects Anemia, Aplastic Drug Therapy Directive Counseling Fluoxymesterone Gynecomastia Chemically Induced Adult Administration & Dosage Blood Psychology Humans Male Sexual Maturation Treatment Outcome Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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