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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Angela S. Twigg, Stephen M. |
| Description | Author Affiliation: Lee AS ( Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia Sydney Medical School and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.); Twigg SM ( Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia Sydney Medical School and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.) |
| Abstract | A 74-year-old man with known metastatic haemangiopericytoma presented with neuroglycopaenic symptoms of confusion and light-headedness secondary to recurrent episodes of fasting hypoglycaemia, which resolved with oral carbohydrate intake. Investigations for hypoglycaemia revealed it to be non-insulin mediated, and subsequently due to a rare paraneoplastic phenomenon termed as non-islet cell tumour hypoglycaemia caused by tumoural overproduction of high molecular weight insulin-like growth factor-II. Despite his underlying malignancy being incurable, directed multimodality treatment involving regular oral carbohydrate intake, glucocorticoid therapy and recombinant human growth hormone was effective in relieving symptoms of hypoglycaemia. We discuss the importance of a systematic diagnostic approach to hypoglycaemia fulfilling Whipple's triad, as specific therapies can be invaluable to improving quality of life. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antineoplastic Agents, Hormonal Therapeutic Use Hemangiopericytoma Complications Hypoglycemia Insulin-Like Growth Factor II Biosynthesis Insulinoma Diagnosis Liver Neoplasms Lung Neoplasms Palliative Care Methods Aged Combined Modality Therapy Dexamethasone Administration & Dosage Dietary Carbohydrates Dizziness Etiology Glucocorticoids Drug Therapy Human Growth Hormone Humans Metabolism Male Quality Of Life Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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