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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Narula, Navneet Horn, Evelyn M. Purga, Scott L. Karas, Maria G. |
| Description | Author Affiliation: Purga SL ( Department of Internal Medicine, NYP/Weill Cornell Medical College, New York, New York, USA.); Narula N ( Department of Pathology, Weill Cornell Medical College, New York, New York, USA.); Horn EM ( Department of Cardiology, Weill Cornell Medical College, New York, New York, USA.); Karas MG ( Department of Cardiology, Weill Cornell Medical College, New York, New York, USA.) |
| Abstract | A 78-year-old woman with metastatic low-grade serous ovarian cancer presented with rapidly progressive exertional dyspnoea and hypoxia, and was found to have new-onset severe pulmonary hypertension (PH) by right heart catheterisation. A diagnosis of pulmonary tumour thrombotic microangiopathy (PTTM) was made at autopsy. PTTM is a rare complication of advanced cancer that often presents as rapidly progressive PH or acute hypoxic respiratory failure. Widespread tumour cell emboli in the pulmonary arteries and arterioles are hypothesised to induce fibrocellular subintimal proliferation and microthrombi, leading to increased pulmonary vascular resistance and PH. PTTM arising from serous ovarian cancer is exceedingly rare, with only two previously reported cases. A discussion of the pathophysiology, diagnosis and management of PTTM is presented. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cystadenocarcinoma, Serous Secondary Hypertension, Pulmonary Complications Lung Neoplasms Pathology Neoplasms, Glandular And Epithelial Neoplastic Cells, Circulating Ovarian Neoplasms Pulmonary Embolism Thrombotic Microangiopathies Diagnosis Aged Autopsy Drug Therapy, Combination Female Humans Drug Therapy Radiography, Thoracic Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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