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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Peet, Aleksandr Pajuväli, Anett Roosimaa, Mart Tillmann, Vallo |
| Description | Author Affiliation: Roosimaa M ( Children's Clinic of Tartu University Hospital, Tartu, Estonia Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.); Pajuväli A ( Faculty of Medicine, University of Tartu, Tartu, Estonia.); Peet A ( Children's Clinic of Tartu University Hospital, Tartu, Estonia Department of Pediatrics, University of Tartu, Tartu, Estonia.); Tillmann V ( Department of Pediatrics, University of Tartu, Tartu, Estonia Department of General Paediatrics, Children's Clinic of Tartu University Hospital, Tartu, Estonia.) |
| Abstract | A 17-year-old girl with McCune-Albright syndrome (MAS) was suspected of having central hypothyroidism based on an inappropriately normal thyroid-stimulating hormone (TSH) and low free thyroxine (fT4). She was clinically euthyroid and her pituitary appeared normal on MRI. Treatment of hypothyroidism with levothyroxine resulted in suppression of TSH with a low fT4 and high free triiodothyronine (fT3) concentration and hence iatrogenic hyperthyroidism was diagnosed. After discontinuation of levothyroxine, the TSH and fT3 normalised while fT4 remained low. Increased conversion of thyroxine (T4) to triiodothyronine (T3) can be part of MAS. Therefore, fT3 and fT4 should both be measured when evaluating thyroid function in patients with MAS. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Fibrous Dysplasia, Polyostotic Blood Hyperthyroidism Hypothyroidism Thyroxine Adolescent Female Complications Humans Chemically Induced Drug Therapy Etiology Adverse Effects Triiodothyronine Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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