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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Morris, Rachel Matthes, Jean |
| Description | Author Affiliation: Morris R ( Neonatal Department, Abertawe Bro Morgannwg University Health Board, Swansea, UK.); Matthes J ( Neonatal Department, Abertawe Bro Morgannwg University Health Board, Swansea, UK.) |
| Abstract | A late preterm presented with tachypnoea, jitteriness, irritability and low grade fever. Blood gas showed a compensated metabolic acidosis. His mother was taking the selective serotonin reuptake inhibitor (SSRI) fluoxetine, 60â mg/day, and he was exclusively breast-fed. The baby's serum level of fluoxetine on day 8 was within the adult therapeutic range and his symptoms were ascribed to fluoxetine toxicity. On changing to formula feeds, his symptoms resolved. SSRIs are commonly administered during pregnancy, but SSRI toxicity in infants is rarely reported. It is possible that this condition is under diagnosed or, alternatively, misdiagnosed as SSRI withdrawal in breast fed infants whose mothers are on SSRIs. There is limited research looking at serotonin excess in neonates, making case reports such as this important in our learning. Increased awareness may prompt more frequent measurements of blood levels in breast-fed infants whose mothers are on SSRIs. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Breast Feeding Adverse Effects Fluoxetine Infant, Newborn, Diseases Etiology Pregnancy Complications Serotonin Syndrome Serotonin Uptake Inhibitors Serotonin Metabolism Adult Bottle Feeding Depressive Disorder Complications Drug Therapy Female Therapeutic Use Humans Infant, Newborn Male Pregnancy Therapy Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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