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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ng, Mansum Gupta, Rajesh Elsayed, Hesham Rutherford, Mary |
| Description | Author Affiliation: Elsayed H ( Department of Paediatrics, Barts Health, London, UK.); Ng M ( Department of Paediatrics, Tunbridge Wells Hospital, Tunbridge Wells, UK.); Rutherford M ( Centre for the Developing Brain, King's College London, London, UK.); Gupta R ( Department of Paediatrics and Neonates, Tunbridge Wells Hospital, Tunbridge Wells, UK.) |
| Abstract | Fetal and neonatal haemolytic diseases result from maternal allo-immunisation to fetal antigens. Maternal antibodies cross the placenta causing red cell haemolysis, resulting in fetal anaemia and, in severe cases, hydrops and perinatal death. Intravascular intrauterine blood transfusion (IUT) has markedly reduced perinatal mortality and is now a standard procedure. IUT is considered to be a safe procedure with fetal loss rate reported to be less than 5% and no reported increase in the rate of neurodevelopment impairment. In this report, we are presenting a case of bilateral cystic encephalomalacia following fetal anaemia secondary to anti-Kell iso-immunisation treated with multiple IUTs. Such a significant adverse outcome following IUT for anti-Kell iso-immunisation has not been reported in the literature. This case highlights the need for appropriate parental counselling and routine postnatal head ultrasound in all babies delivered following multiple IUTs. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Blood Transfusion, Intrauterine Adverse Effects Cerebral Palsy Diagnosis Encephalomalacia Immunology Fetal Diseases Kell Blood-Group System Rh Isoimmunization Complications Adult Anemia Embryology Therapy Directive Counseling Echoencephalography Pathology Female Humans Infant Infant, Newborn Male Parents Psychology Pregnancy Prevention & Control Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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