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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Najem, Catherine E. Yadav, Rajwardhan Carlson, Elise |
| Description | Author Affiliation: Najem CE ( Department of Internal Medicine, Roger Williams Medical Center, Providence, Rhode Island, USA.); Yadav R ( Department of Rheumatic and Immunologic Diseases, Yale New Haven Hospital, New Haven, Connecticut, USA.); Carlson E ( Department of Rheumatic and Immunologic Diseases, Yale New Haven Hospital, New Haven, Connecticut, USA.) |
| Abstract | Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare eosinophil-rich disorder characterised by necrotising granulomatous inflammation affecting small to medium sized vessels. Extrapulmonary manifestations can be life-threatening when heart, central nervous system (CNS), gastrointestinal tract or kidneys are affected. We describe a case of a 56-year-old woman with a long-standing history of asthma, who presented with an acute sudden painless loss of vision after she had been recently diagnosed with EGPA and induced with pulse steroids and cyclophosphamide. The patient had a complicated hospital course with multisystemic involvement of active vasculitis, involving heart, kidneys, muscles, eyes and CNS. The patient's devastating condition responded remarkably to Rituximab. The role of Rituximab in EGPA is not yet proven. Few cases are reported in the literature about the role of Rituximab in EGPA, of which only one described retinal artery occlusion as a presentation of a recently treated patient with EGPA. |
| Volume Number | 2015 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Churg-Strauss Syndrome Drug Therapy Granulomatosis With Polyangiitis Immunosuppressive Agents Therapeutic Use Rituximab Asthma Complications Blindness Etiology Cyclophosphamide Adverse Effects Eosinophilia Eosinophils Metabolism Female Hospitalization Humans Inflammation Middle Aged Rare Diseases Retinal Artery Occlusion Steroids Case Reports Journal Article Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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