Fetal Brain Injury in Rhesus Isoimmunization Fetus.

Content Provider	Europe PMC
Author	Al Sanei, Eman Elbatreek, Mostafa Sallout, Rula B Al Baqawi, Badi Sallout, Bahauddin I
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2022
Abstract	This report presents a rare fetal and neonatal complication brain injury (encephalomalacia and ventriculomegaly) as a consequence of severe fetal anemia resulting from Rhesus (Rh) isoimmunization. A 28-year-old gravida 4 para 3 woman was referred at 21+4 weeks of gestation to the fetal medicine clinic as a case of Rh isoimmunization. Fetal ultrasound showed a normal anatomy scan with normal brain structure, but with severe fetal anemia. The patient was treated with multiple intrauterine transfusions, but still developed complications post-transfusions. This case shows that severe cerebral developmental anomalies can occur because of severe fetal anemia secondary to Rh isoimmunization, such as in this case - ventriculomegaly and encephalomalacia. It has been concluded that proper antenatal counseling and early intervention for severe fetal anemia are beneficial to prevent such complications from occurring. It is crucial to consider appropriate antenatal and postnatal radiological imaging for such cases.
Journal	Cureus
Volume Number	14
DOI	10.7759/cureus.21450
PubMed Central reference number	PMC8782631
Issue Number	1
PubMed reference number	35103225
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2022-01-20
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	hdrops intrauterine transfusion fetal anemia encephalomalacia ventriculomegaly
Content Type	Text
Resource Type	Case study
Subject	Medicine