NDLI: Correlation between Leukoaraiosis and natural brain tissue velocity: A pilot study using Ultrasound and MRI

Content Provider	IEEE Xplore Digital Library
Author	Ternifi, R. Cazals, X. Desmidt, A.L.T. Camus, V. Cottier, J.P. Patat, F. Remenieras, J.P.
Copyright Year	2012
Description	Author affiliation: Univ. Francois Rabelais, Tours, France (Ternifi, R.; Cazals, X.; Desmidt, A.L.T.; Camus, V.; Cottier, J.P.; Remenieras, J.P.) \|\| CIC-IT 806, CHRU de Tours, Tours, France (Patat, F.)
Abstract	Leukoaraiosis (LA) refers to lesions and rarefaction of the cerebral White Matter (WM) and is frequently seen in aged individuals. Although the mechanism of LA remains unknown, a decrease in cerebral perfusion is suspected to be linked to LA. LA can be seen in individuals without any clinical abnormality, however new findings suggest that LA may be clinically relevant [1,2]. Patients with LA have a decreased prognosis in term of death, stroke and myocardial infarction occurrences. The aim of our work was to study the relationship between LA and the natural brain tissue velocity due to pulsed cerebral perfusion. Brain velocities were measured with an analog of the Tissue Pulsatility Imaging (TPI) method described by Kucewicz [3,4], which has been already used in our group for depressed patients [5]. Thirteen voluntary healthy women aged between 60 and 85 were enrolled in this cross-sectional study. Transcranial acquisitions were performed with a 2 MHz phased-array probe through the right temporal bone window and off-line estimations of velocity were performed by correlation on the RF signals. MRI examinations were performed on a 1.5T GE system using dedicated software (MRIcro) to obtain a volumetric analysis. The primary endpoints of the study were the maximum brain tissue velocity (TPImax), the absolute MRI volume of WM hyperintensity (VAbs) and the relative volume (VRel) on the right hemisphere. The Spearman correlation coefficient was used for statistical analysis. Our main finding is that TPImax decreases significantly when the severity of LA increases. Significant negative correlation between TPImax and VRel (ρ= -0.81, p <; 0.01) is observed despite the small size of our recruitment. LA and other neurodegenerative pathologies being considered to have a strong link with brain vascular defects, the ultrasonic TPI method appears to be valuable and promising.
Starting Page	945
Ending Page	948
File Size	420575
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0236
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Brain Magnetic resonance imaging Diseases Correlation Aging leukoaraiosis brain pulsatility tissue velocity
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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