NDLI: Nondestructive mechanical testing of human knee meniscus allografts using MSSER ultrasound: A feasibility study

Content Provider	IEEE Xplore Digital Library
Author	Czernuszewicz, T.J. Charoenpanich, A. Loboa, E.G. Gallippi, C.M.
Copyright Year	2012
Description	Author affiliation: Joint Dept. of Biomed. Eng., Univ. of North Carolina, Chapel Hill, NC, USA (Czernuszewicz, T.J.; Charoenpanich, A.; Loboa, E.G.; Gallippi, C.M.)
Abstract	Researchers have begun to investigate novel meniscus graft construction with donor cell replacement through decellularization and host stem cell seeding. In these techniques, there is an unmet need for a nondestructive mechanical testing platform that can monitor changing mechanical properties of the seeded graft over time. In this study, Monitored Steady-State Excitation and Recovery (MSSER) ultrasound, which exploits multiple successive acoustic radiation force excitations interspersed with tracking lines to mimic a materials creep test, was used to nondestructively test the mechanical stiffness of meniscus grafts. Four human meniscus samples were evaluated ex vivo using MSSER: two chemically decellularized samples and two intact samples. MSSER testing measured a median stiffness difference of 37% between intact and decellularized samples, which agreed well with the 35% difference measured by destructive compression testing. Volumetric MSSER scanning showed highly heterogeneous stiffness throughout the samples. This demonstration substantiates the use of MSSER as a relevant nondestructive testing tool in tissue engineering applications.
Starting Page	1347
Ending Page	1350
File Size	1505279
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0336
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Steady-state Testing Imaging Acoustics Displacement measurement Ultrasonic imaging Monitoring non-destructive acoustic radiation force MSSER meniscus tissue engineering
Content Type	Text
Resource Type	Article

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